Metabolic Health
Kosher supplements for metabolic longevity
Insulin sensitivity, glucose regulation, and mitochondrial function are central to longevity. These are the evidence-graded kosher options — from Berberine's head-to-head metformin comparisons to NMN's promising insulin sensitivity data.
Evidence tiers apply across this page. Tier 1 = human RCTs with meaningful endpoints. Tier 2 = human RCT data, not longevity primary endpoints. Tier 3 = limited or mechanistic human data. Community = no evidence tier; kashrut notes only. See full ranked list →
Magnesium Glycinate
Tier 1
200–400 mg elemental/day
Depleted by diabetes medications and PPIs. Meta-analysis: improved insulin sensitivity, fasting glucose. OU certified.
NMN
Tier 2
250–500 mg/day
Yoshino 2021: 25% improvement in muscle insulin sensitivity in prediabetic women. NAD+ precursor. Pareve fermentation.
Berberine
Tier 2
500 mg 3×/day
HbA1c −2.0% in Zhang 2008 RCT — comparable to metformin. Most studied natural metabolic agent. OU available.
Alpha-Lipoic Acid (R-ALA)
Tier 3
300–600 mg/day
Human RCTs for diabetic neuropathy and glucose metabolism. R-form preferred. Synthetic = pareve.
Taurine
Tier 2
1–3 g/day
Emerging data on mitochondrial function and metabolic aging. Verify synthetic (pareve) source — animal-derived is common.
Spermidine
Tier 3
1–3 mg/day
Autophagy inducer. Observational data links dietary spermidine to lower metabolic disease mortality. Wheat-derived — chametz on Pesach.
Take something else for metabolic health? Source it through our dispensary.
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