Clinical Resources

Built for practitioners who read
the primary literature.

Every ranking, rating, and tool on this site is grounded in published human trial data. No marketing claims, no proprietary blends, no affiliate-driven recommendations. This page consolidates the resources most useful to clinicians working with patients on longevity.

Jump to resources Evidence methodology
9 clinical tools — all free
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Safety
Drug–Nutrient Depletion Checker
50+ drugs mapped to the nutrients they deplete — statins, metformin, PPIs, diuretics, SSRIs — with depletion mechanism and repletion evidence.
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Evidence
Medication Reality Check
NNT, NNH, absolute vs. relative risk for 50+ commonly prescribed drugs. Useful for shared decision-making when patients ask about actual benefit magnitudes.
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Patient Tools
Physician Pre-Visit Prep Guide
Printable patient preparation guide — structured questions about supplements, biomarkers, and longevity interventions. Reduces appointment time spent on basics.
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Safety
Supplement Contraindications
Condition-specific supplement safety flags — anticoagulation, thyroid effects, hormone-sensitive conditions, surgery prep, and CKD considerations.
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Comparison
Supplement Evidence Comparison
Head-to-head comparison of any two supplements by evidence grade, mechanism, dose, form, and trial quality. Useful when patients present multiple options.
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Diagnostics
Biological Age Tests Compared
TruDiagnostic, Elysium Index, DunedinPACE compared by clock type, validated endpoints, clinical utility, and evidence quality.
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Diagnostics
Longevity Biomarker Panel Guide
Prioritized testing guide — which labs give the most actionable longevity data, optimal vs. standard reference ranges, which interventions move each marker.
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Methodology
Our Evidence Grading System
How we grade supplements — human RCT requirement, dose-form matching, bioavailability scoring, third-party verification, and COI audit. Tiers A through D with examples.
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New — Conditions
Condition-Specific Nutrition
Evidence-graded nutrition for heart health, insulin resistance, high LDL, hypertension, fatty liver, and osteoporosis — with medication cautions and PubMed citations on every page.
Our Standard

What we mean by evidence-based

The longevity supplement space has a methodological problem: most sites cite human studies without checking dose-form matching, conflict of interest, or outcome quality. Our grading addresses this directly.

Human trials only, first gate
No compound reaches Tier A or B without human RCT data. Animal studies and mechanistic data are noted but do not drive tier assignment. This eliminates the majority of marketed longevity supplements from top tiers.
Dose and form must match the trial
We check whether the dose and form a product sells matches the dose and form used in the human trial cited. Most curcumin products use standard powder (<1% bioavailability) while all efficacy trials use enhanced forms.
COI audit on every citation
We flag studies funded by supplement manufacturers and weight manufacturer-funded RCTs lower than independent trials. Where only manufacturer-funded studies exist, this is noted explicitly on the product page.
Products are not accepted for placement
No product is ranked by paid placement, sponsorship, or affiliate revenue share. Affiliate links are added after ranking — never before — and never affect a product's tier or ranking position.
How supplements are graded

The four-tier evidence system

Tier A
5/5
Multiple independent human RCTs · Hard longevity-adjacent endpoints · Dose and form match · Independent replication
Omega-3 EPA/DHA · Magnesium glycinate · Vitamin D3+K2 · CoQ10 Ubiquinol · Creatine · Berberine
Tier B
4/5
Human RCT evidence · Meaningful surrogate endpoints · Some form/dose match
NMN · Niagen (NR) · Curcumin Phytosome · Quercetin · Ashwagandha KSM-66 · Taurine · Melatonin
Tier C
3/5
Limited human trials · Mostly mechanistic or animal data · Promising signal
Spermidine · Fisetin · Lion's Mane · Astaxanthin · EGCG · Rhodiola · PQQ
Tier D
2/5
Preclinical data only · No human RCT · Theoretical mechanism
Epithalon · Klotho pathway compounds · Emerging peptide protocols
Not Listed
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No credible human evidence · Implausible mechanism · Marketing-only claims
Quantum energy products · "Tachyon-charged" amino acids · Frequency-based devices with no mechanism

Tiers are reassessed when significant new human trials are published. Full methodology → · Evidence changelog →

Evidence tiers reflect published human RCT data as of Q2 2026. Affiliate links may generate revenue but are applied after ranking and never influence product placement. Educational only — not medical advice. Disclosure · Privacy