" Antipsychotics (Risperidone, Quetiapine, Haloperidol) Nutrient Depletions — Evidence-Based Replenishment Guide | Evidence Based Longevity
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Drug Nutrient Depletion Guide

Antipsychotics: What It Depletes and How to Replenish

Antipsychotic medications are associated with clinically documented depletion of 3 key nutrients, with particular impact on metabolic and neurological cofactors.

Brand names: Risperdal, Seroquel, Abilify, Haldol, Zyprexa

This page is educational content based on published clinical trials. All supplement recommendations should be discussed with your prescribing physician before implementation. Evidence ratings follow the same RCT-first methodology used across the full Evidence Based Longevity database.
3 Documented Depletions · RCT Evidence
1
CoQ10 (Ubiquinol)
Moderate Depletion Risk
How It Depletes

Atypical antipsychotics impair mitochondrial electron transport chain function and reduce CoQ10 synthesis. This contributes to metabolic side effects including weight gain and insulin resistance.

Clinical Evidence

Vevera et al. (Psychiatry Res, 2013) — significantly lower CoQ10 in schizophrenia patients on antipsychotics vs. drug-naive patients. Mitochondrial dysfunction implicated in antipsychotic-induced metabolic syndrome.

Symptoms of Deficiency

Fatigue, metabolic syndrome, muscle weakness, cognitive dulling

Evidence-Based Replenishment

Ubiquinol 200–300mg daily with fat-containing meal for absorption.

View on Fullscript: Life Extension Super Ubiquinol CoQ10

Discuss with your physician before adjusting supplementation. This is educational content, not medical advice.

2
Vitamin B6 (P5P)
Moderate Depletion Risk
How It Depletes

Antipsychotics interfere with B6-dependent enzyme systems including dopamine and serotonin synthesis pathways. Phenothiazine-class antipsychotics directly antagonize B6 coenzyme activity.

Clinical Evidence

Lerner et al. (J Clin Psychiatry, 2002) — B6 supplementation (1,200mg/day) significantly reduced akathisia (drug-induced movement disorder) in antipsychotic patients. B6 depletion linked to tardive dyskinesia risk.

Symptoms of Deficiency

Akathisia (restlessness), tardive dyskinesia risk, peripheral neuropathy, depression

Evidence-Based Replenishment

P5P (pyridoxal-5-phosphate, active form) 25–50mg daily. Use active P5P form, not pyridoxine — superior bioavailability.

View on Fullscript: Thorne P-5-P (Pyridoxal 5'-Phosphate)

Discuss with your physician before adjusting supplementation. This is educational content, not medical advice.

3
Melatonin
Moderate Depletion Risk
How It Depletes

Many antipsychotics — particularly olanzapine and risperidone — suppress nocturnal melatonin secretion via dopamine receptor antagonism. Disrupts circadian rhythm and worsens sleep architecture.

Clinical Evidence

Shamir et al. (Schizophrenia Res, 2000) — antipsychotics significantly lower nighttime melatonin; supplementation improved sleep quality. Kunz & Bes (J Pineal Res, 1999) confirmed suppressive effect.

Symptoms of Deficiency

Insomnia, disrupted sleep architecture, circadian dysregulation, tardive dyskinesia (melatonin has antioxidant protective role)

Evidence-Based Replenishment

Melatonin 0.5–3mg 30 minutes before bed. Start low. Use slow-release for sleep maintenance vs. immediate release for sleep onset.

View on Fullscript: Pure Encapsulations Melatonin 0.5mg

Discuss with your physician before adjusting supplementation. This is educational content, not medical advice.

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